What is your greatest weakness?

I have spent a great deal of time moving from one job to the next, and I have always loathed this interview question. What’s the best way to handle this question? My standard answer is I can get too focussed on one project, it’s benign enough to be inconsequential. But here’s a great piece on how according to Freakonomics & game theory it’s a net loss question for the interviewee with no incentive for an honest answer, check it out.